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Christie, A. B. et al. (1974),Infectious Diseases: Epidemiology and Clinical Practice,2nd Ed. Churchill Livingstone. Crump J. A. et al. The global burden of typhoid fever. Bulletin of the World Health Organisation (2004),82: 346-353. Felix A. and Pitt R.M. Virulence and immunogenic activities of B.Typhosus in relation to its antigenic constituents. J. Hyg. (1935), 35: 428-436. Gupta, A .Swarnkar… Continue reading REFERENCES

DESCRIPTION & INDICATION: A clear to slightly turbid solution containing purified Vi capsular polysaccharide of Salmonella typhi (Strain Ty2) conjugated with Tetanus toxoid protein for prevention of typhoid fever. The manufacturing facilities meets the requirements as per cGMP guidelines of revised schedule ‘M’ from the Drugs & Cosmetic Act, Government of India. COMPOSITION : One… Continue reading PRESCRIBING INFORMATION-Peda Typh TM ( Vi Conjugate typhoid vaccine )

Introduction  The studies were undertaken to assess the immunogenicity and safety in infants and older children of a new vaccine-Vi polysaccharide conjugated with Tetanus toxoid protein, developed by Dr. Puneet Garg & his associates at BIO MED(P) ltd, Ghaziabad, INDIA. This new technology has avoided the use of recombinant proteins for conjugation. The vaccine has… Continue reading CLINICAL TRIAL OF Vi CONJUGATE TYPHOID VACCINE (Peda TyphTM)

Typhoid vaccines are known to the medical science for more than a century. Wright in 1896 introduced typhoid vaccine for the first time. Vi polysaccharide of S. typhi was recognized as the only important antigen involved in inducing protective antibodies Felix & Pitt(1935).The new type of typhoid vaccines were developed by reexamination of the protective role of the… Continue reading TYPHOID VACCINES

Until recently , typhoid was considered a disease of children above 3-5 years since it presented itself in an atypical clinical picture in infants and young children. This was further hampered due to difficulty in getting enough blood samples for appropriate culture isolation. The laboratories were not well equipped with good quality media, reagents &… Continue reading RECENT ADVANCES IN UNDERSTANDING OF TYPHOID FEVER IN INFANTS

Typhoid fever exhibits in various forms. Typically, it starts with malaise, anorexia, muscular  aches and fevers,that increases everyday by 0.25-0.50C to reach to 39 to 410 C coupled with abdominal pain & headaches. Fever rises to 410 C in 5-7 days where it stays for 10-15 days if untreated, then fever decreases slowly over several days. During the… Continue reading CLINICAL PICTURE OF TYPHOID FEVER

The epidemiology of the typhoid fever primarily involves person to person spread because this organism lacks an animal reservoir. Faecal contamination is the major mode of spread and the usual vehicle is contaminated water. An asymptomatic human carrier state exists. The carrier state may last for many weeks to years providing human reservoir. The incidence… Continue reading TYPHOID FEVER – EPIDEMIOLOGY

Typhoid fever has been reported from all parts of the world. With the improvement in sanitation and standard of living, the disease is now uncommon in developed countries. However, in developing and under-developed countries, it is still one of the major infectious disease having significant mortality and morbidity. It has been estimated that globally about… Continue reading TYPHOID FEVER – INTRODUCTION